detailed program

Program

Saturday May 14, 2022

3:00 PM      Registration

7:00 PM      Dinner

8:10 PM      Welcome addresses (includes sponsor presentations: FEMS and ISHAM)

8:40 PM      Keynote lecture

                   Chair: Ana Traven

                   Bernhard Hube (Hans-Knöll-Institut, Germany) (Journal of Fungi-sponsored lecture)

                   The commensalism­to­pathogen shift of Candida albicans

9:30 PM      Welcome Reception

Sunday May 15, 2022

7:30 AM      Breakfast

8:00 AM      Registration

8:30 AM      Session 1: Clinical challenges and epidemiology of fungal infections (Gilead-sponsored Session)

8:30 AM      Frank van de Veerdonk (Radboud Institute for Molecular Life Sciences, The Netherlands)

                   Introduction

8:50 AM     Ilan Schwartz (University of Alberta, Canada)

                   The evolving landscape of the endemic mycoses

9:20 AM      Darius Armstrong-James (Imperial College London, UK)

                   Pathogen and host determinants of clinical endotypes in chronic respiratory aspergillosis

9:50 AM     Coffee Break

10:20 AM    Anuradha Chowdhary (University of Delhi, India)

Fungal outbreaks in healthcare settings: implications for diagnosis and antifungal resistance

10:50 AM    Jeremy Day (Oxford University Clinical Research Unit, Vietnam)

Cryptococcal meningitis in Vietnam ­ unpicking the relationship between pathogen and patient       

11:20 AM    Dominique Sanglard (Institut universitaire de microbiologie, Switzerland)

                   Drug resistance in clinical isolates of Candida spp: behind the curtains

12:15 PM    Lunch

3:30 PM      FEBS presentation

3:45 PM      Workshop 1: Clinical challenges and epidemiology of fungal infections

                   Chairs: Ilse Jacobsen and Oliver Bader

3:45 PM      Jeffrey Rybak (St. Jude Children's Research Hospital, USA)

A novel Candida auris single nucleotide gene editing system reveals the direct impact of mutations in FKS1 on echinocandin resistance

4:00 PM      Katherine Gonzalez Rohas (Hans Knöll Institute, Germany)

                   Drug delivery systems to target Aspergillus fumigatus conidia inside macrophages

4:15 PM      Jerome Govin (Institute of Advanced Biosciences, France)

                   BET bromodomain inhibition as a potential new antifungal therapeutic strategy

4:30 PM      Angela Rivera (Duke University, USA)

Developing rapamycin analogs as a novel antifungal therapy approach for fungal infections

4:45 PM      Coffee Break

5:15 PM      Elevator talks, Session 1

                   Chair: Elaine Bignell

5:15 PM      Daria Kosmala (Institut Pasteur, France)

                   Pathogenic potential of Candida africana

5:21 PM      Bernardo Ramírez-Zavala (University of Würzburg, Germany)

The protein kinase Ire1 has a Hac1­independent essential role in iron uptake and virulence of Candida albicans

5:27 PM      Daniel Murante (Dartmouth College, USA)

Repeated selection for the induction of iron acquisition pathways in CF Repeated selection for the induction of iron acquisition pathways in CF

5:33 PM      Eduardo Gushiken-Ibañez (University of Zurich, Switzerland)

Aryl hydrocarbon receptor (AhR) signaling in the host response against the skin commensal yeast Malassezia during health and disease

5:39 PM      Anna Zimmermann (University of Würzburg, Germany)

Pathogenicity and genomic features of different Fusarium solani keratitis isolates in a human corneal infection model

5:45 PM      Diana Tamayo (University of Exeter, UK)

                   Cryptococcus neoformans titan cells: Why does the small become big?

5:51 PM      Adam Taheraly (Institut Pasteur, France)

                   Extracellular vesicle RNA in Cryptococcus

5:57 PM      Ann-Kristin Kaune (Univeristy of Aberdeen, UK)

                   Genotypic and phenotypic analysis of cell surface variability in Candida albicans

6:03 PM      Hossein Arzani (Medical University of Vienna, Austria)

                   The role of the T helper cells in the Candida auris skin response

6:09 PM      Edel Hyland (Queen's University, UK)

                   Targeting chromatin structure to tackle anti­fungal resistance in Candida glabrata

7:00 PM      Dinner

8:00 PM      Poster session 1

Monday May 16, 2022

7:30 AM      Breakfast

8:30 AM      Session 2: Molecular and Cell Biology of Fungal Pathogens

8:30 AM      Carol Munro (University of Aberdeen, UK)

                   Introduction

8:50 AM     Maurizio del Poeta (Stony Brook University, USA) (Elsevier-sponsored lecture)

Cryptococcus neoformans delta­sgl1 is a promising vaccine candidate against cryptococcosis

9:20 AM      Slavena Vylkova (Hans Knöll Institute, Germany)

Amino acid metabolism plays a central role in Candida albicans adaptation to the host environment

9:50 AM     Coffee Break

10:20 AM    Giuseppe Ianiri (University of Molise, Italy) (Chromagar-sponsored lecture)

                   Genomics and genetics in the skin commensal and pathogenic Malassezia yeasts

10:50 AM    Michael Bromley (University of Manchester, UK)

Competitive fitness profiling of A. fumigatus mutants can be used to identify novel fungal virulence factors and suppressors of drug resistance

11:20 AM    Xiaorong Lin (University of Georgia, USA)

                   Pan antifungal targeted drug delivery and cryptococcal vaccination

12:15 PM    Group Photo

12:30 PM: Lunch

3:45 PM      Workshop 2: Molecular and Cell Biology of Fungal Pathogens

                   Chairs: Delma Childers and Sneh Panwar

3:45 PM      Valeria Tava (Università degli studi di Milano, Italy)

Are there differences between F. musae strains isolated from banana fruits and humans?

4:00 PM      Rebecca Hall (University of Kent, UK)

Identification of secreted bacterial products that display antifungal activity towards the Mucormycetes

4:15 PM      Edward Wallace (The University of Edinburgh, UK)

A conserved fungal virulence factor, Ssd1, regulates the translation of cell wall proteins and evolved from proteins with a different molecular function

4:30 PM      Evelina Tutucci (VU Amsterdam University, The Netherland)

Development of a spatial gene expression profiling method to characterize Candida albicans biofilm formation

4:45 PM      Coffee Break

5:15 PM      Elevator talks, Session 2

                   Chair: Mike Lorenz

5:15 PM      Elizabeth Edrich (University of Kent, UK)

The role of mitochondria and the electron transport system (ETS) in Cryptococcus neoformans pathogenesis

5:21 PM      Olivia Paulin (King’s College London, UK)

Using CRISPR to uncover the relationships between virulence factors in Candida albicans

5:27 PM      Françios Olivier (Monash University, Australia)

The escape of Candida albicans from macrophages is enabled by gasdermin D and candidalysin

5:33 PM      Hannah Wilson (University of Texas Health Science Center at Houston, USA)

Determining the contributions of C. albicans metabolism and morphogenesis to phagosomal alkalinization

5:39 PM      Lasse van Wijlick (Institut Pasteur, France)

Metal and Sex: The Candida albicans CCAAT­binding transcription factor Hap5 links iron homeostasis to mating

5:45 PM      Hasan Dawi (University of Grenoble Alpes, France)

Targeting BET bromodomains of Candida auris with small molecule inhibitors as a potential new antifungal strategy

5:51 PM      Emer Hickey (University of Exeter, UK)

                   Fungal memory and adaptive prediction in the gut

5:57 PM      Evelyn Zuniga (University college Dublin, Ireland)

                   Genotype and phenotype variation in Candida parapsilosis

6:03 PM      Hervé Begue (University of Burgundy, France)

Impact of agricultural chemical inputs on the intestinal microbiota: the example of the yeast Candida albicans

6:09 PM      Justyna Karkowska-Kuleta (Jagiellonian University, Poland)

Extracellular vesicles released by Candida tropicalis - by exploring the structure and composition to understand the functionality

7:00 PM      Dinner

8:00 PM      Poster session 2

Tuesday May 17, 2022

7:30 AM      Breakfast

8:15 AM      Session 3: Microbiome and microbial interactions

8:15 AM     Salomé LeibundGut-Landmann (University of Zurich, Switzerland)

                   Introduction

8:35 AM     Clarissa Nobile (University of California Merced, USA)

                   Candida biofilms: importance, regulation, and evolution

9:05 AM      Tobias Hohl (Memorial Sloan Kettering Cancer Center, USA)

                   Tracking Fungal Reservoirs and Resistance in the Mycobiota to Prevent Human Disease

9:35 AM     Soo Chan Lee (University of Texas San Antonio, USA)

                   Differential mycobiome dysbiosis in CD, UC, and IBS

10:05 AM    Coffee Break

10:35 AM    Session 4: Crossing disciplines: Beyond mycology

10:35 AM    Oliver Kurzai (University of Würzburg, Germany)

                   Introduction

10:55AM     Marc Thilo Figge (Hans Knoll Institute, Germany)

                   Image­based systems biology: from images to numbers      

11:25 AM    Ana Alastruey-Izquierdo (Instituto de Salud Carlos III, Spain)

                   The WHO Fungal Priority Pathogen List: methodology and main gaps detected

12:55 PM    Hailing Jin (University of California, USA)

Cross­kingdom mRNA trafficking from a plant host to a fungal pathogen via extracellular vesicles to suppress infection

12:30 PM    Lunch

Free Afternoon and evening

Wednesday May 18, 2022

7:30 AM      Breakfast

8:30 AM      Session 5: Host-Pathogen Interactions: the host's perspective

8:30 AM      Gordon Brown (University of Exeter, UK)

                   Introduction

8:50 AM     Rebecca Drummond (University of Birmingham, UK)

                   Fungi on the brain: how do microglia respond to fungal invasion of the CNS?

9:20 AM      Jessica Quintin (Institut Pasteur, France) (SFMM-sponsored lecture)

                   Opposing effects of fungal beta­glucan­induced memory on macrophages

9:50 AM     Coffee Break

10:20 AM    Mihai Netea (Radboud University Medical Center, The Netherlands)

                   Genetic and immune factors influencing susceptibility to vaginal candidiasis

10:50 AM    Teresa Zelante (Università degli studi di Perugia, Italy)

Radiation therapy­dependent oral mucositis: how the oral dysbiosis may predispose to fungal infections        

11:20 AM    Agostinho Carvalho (Life and Health Sciences Research Institute, Portugal) (ECMM-sponsored lecture)

                   Metabolic control of immune cell function during fungal infection

12:15 PM    Lunch

3:45 PM      Workshop 3: Host-Pathogen Interactions: the host's perspective

                   Chairs: Reeta Rao and Duncan Wilson

3:45 PM      Leijie Jia (Hans Knoell Institute, Germany)

Human p11­mediated re­direction of phagosomes to the recycling endosome­expulsion pathway induced by fungal pathogen

4:00 PM      Maxime Höft (University of Cape Town, South Africa)

Understanding the host immune response to Emergomyces africanus, a new endemic emerging fungal pathogen

4:15 PM      Marc Swidergall (Harbor-UCLA Medical Center, USA)

IL­23 signaling prevents ferroptosis­driven renal immunopathology during candidiasis

4:30 PM      Attila Gacser (University of Szeged, Hungary)

Candida albicans enhances the development and progression of oral squamous cell carcinoma in vitro and in vivo

4:45 PM      Coffee Break

5:15 PM      Elevator talks, Session 3

                   Chair: Greetje Vande Velde

5:15 PM      Jana Nysten (KU Leuven, Belgium)

                   Exploring the riboflavin biosynthetic pathway as a new source of antifungal drug targets

5:21 PM      Maria Alvarado González (University of Castilla-La Mancha)

The cell wall proteome of Candida auris and use of unique GPI protein­encoding genes for PCR identification

5:27 PM      Sébastien Ortiz (The University of Manchester, UK)

Morphotype­specific fungal factors drive uptake and clearance of Aspergillus fumigatus by airway epithelial cell

5:33 PM      Laura Seldeslachts (KU Leuven, Belgium)

The wolves in sheep's clothing: Influenza­induced epithelial barrier disruption and neutrophil extracellular traps drive invasive pulmonary aspergillosi

5:39 PM      Minna Ding (University of Minnesota Medical School, USA)

Use of clinical isolates to establish criteria for a mouse model of latent Cryptococcus neoformans infection

5:45 PM      Moran Morelli (Mimetas BV, Netherlands)

Towards an organ­on­a­chip screening platform to identify modulators of the epithelial response to candidalysin

5:51 PM      Valentina del Olmo Toledo (Barcelona Supercomputing Center, Spain)

Genome analysis of Candida orthopsilosis marine isolates unveils the missing parental lineage and suggests an environmental origin of hybrids with pathogenic

5:57 PM      Taylor Schoen (University of Wisconsin-Madison, USA)

Aspergillus fumigatus hyphal branching mutant shows enhanced susceptibility to host defenses and caspofungin in vivo

6:03 PM      Alexandra Soare (University of Maryland, USA)

Suppression of nitric oxide production in activated macrophages by mucormycosis­causing fungi

6:09 PM      Patrick Dancer (University of Manchester, UK)

Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

7:00 PM      Dinner

8:00 PM      Poster session 3

Thursday May 19, 2022

7:30 AM      Breakfast

8:30 AM      Session 6: Host-Pathogen Interactions: the pathogen's perspective

8:30 AM      Elizabeth Ballou (University of Birmingham, UK)

                   Introduction

8:50 AM     Iuliana Ene (Institut Pasteur, France)

                   Small molecules restore azole activity in drug resistant Candida isolates

9:20 AM      Elaine Bignell (University of Exeter, UK)

                   Molecular and chemigenetic analysis of pH adaptation in A. fumigatus

9:50 AM     Coffee Break

10:20 AM    Carolina Coelho (University of Exeter, UK)

Immunometabolic regulation of macrophage function during C. neoformans infection

10:50 AM    Marcio Rodrigues (Instituto Carlos Chagas, Brazil)

                   The functional multitude of fungal extracellular vesicles    

11:20 AM    Jorge Amich (Manchester Fungal Infection Group (MFIG), UK)

Certain Aspergillus fumigatus isolates exhibit persister growth in the presence of the fungicidal drug voriconazole

12:15 PM    Lunch

3:45 PM      Workshop 4: Host-Pathogen Interactions: the pathogen's perspective

                   Chairs: Elvira Roman and Christian Perez

3:45 PM      Robert Wheeler (University of Maine, USA)

Pseudomonas synergizes with fluconazole against Candida during treatment of polymicrobial infection

4:00 PM      Isabelle Mouyna (Institut Pasteur, France)

                   Regulation of the Extracellular Vesicules biosynthesis pathway in Cryptococcus

4:15 PM      Amelia Barber (Leibniz-HKI, Germany)

Aspergillus fumigatus pan­genome analysis identifies genetic variants associated with human infection

4:30 PM      Nicola Case (University of Toronto, Canada)

Global analysis of circuitry governing Candida albicans morphogenesis within host immune cells

4:45 PM      Coffee Break

5:15 PM      Keynote lecture

                   Chair: Guilhem Janbon

                   Bridget Barker (Northern Arizona University, USA) (IUBMB-sponsored lecture)

                   Lessons from the Desert: Coccidioides Ecology, Genomics, and Modes of Reproduction

6:00 PM      Award ceremony

6:30 PM      Drinks, dinner and farewell party